HUANJIA ZHANG

Science, humanity, and everything in between.

This article is originally published by Gettysburg College in April, 2018.
Photo by Pete Vogel

People say life is the best classroom. One year out from college, I couldn’t agree more. Through this year, I have learned many things — things I wish I had known before I threw my cap up in the air, things I wish somebody had written out to caution me before I walked across the podium. And here, I want to spoil them for you, hoping to help you become more prepared for your post-graduation life.

You are more prepared than you think.

Many seniors aren’t confident finding a job at first. I was exactly like you. I spent hours, if not days, staring at my resume, ruminating how to make my only award look more like a ‘Nobel-Prize-of-some-sort,’ or how to word my club president experience so it sounds more like “The President” instead.

Then I learned, and most of you will probably learn, too, regardless of how fancy the job description reads, your first job will be an entry-level job. It will largely involve repetitive work. You will probably never need to apply your “leadership skills” or “crisis management skills”, which you promised to contribute to your “dynamic team” on your cover letter.

With that said, not a lot people are trying to “steal” the jobs that you are applying for. For people with more experience than you, your job is probably too “low” and doesn’t pay well enough. For people with similar experience as you, there are many entry-level jobs to help disperse the competition.

But I am not saying you don’t have to work hard in college. Quite the opposite — you still have to make every effort in college to maintain a decent GPA and actively get involved in curricular/extra-curricular activates. I promise that your resume will have a better chance of standing out during human resources screening and get passed to the hiring manager. But once you’re in the door, believe me — you’re more qualified for the job then you think. So be confident.

There is rarely a warm welcome to the adult world.

Remember the weeklong orientation you had before starting college? Remember the smiling upper-class volunteers who greeted you with thumb-ups as soon as you pulled in the parking lot and raced to help you move in your room? Unfortunately, when you toss your caps, those special treatments will also be tossed away.

There will be no buffer zone for you to switch to the adult life. So be mentally prepared. Your landlord will start to collect the rent as soon as you move in. Your bills will come in your mailbox like lost doves finally returning home. Even though some work places hold orientation sessions, you will most likely be overwhelmed by “blah, blah, blahs” such as health insurance premiums, 401K plans, while being “brainwashed” by the orientation officer with their company missions, philosophy, achievements, and expectations.

It’s better to graduate college with a plan.

So far this is the most important and valuable lesson I have learned from my gap year.

Many graduating seniors decide to take gap years to help figure out what they want to do next. I was definitely one of them. But keep in mind, sometimes it can be trickier to find out your career goals during your gap years than at school. After all, taking gap years is not quite as comparable as wine tasting — it’s not practical to have a taste of multiple jobs until you find your favorite one in just a couple years. Once you graduate — unless you are lucky — you won’t find yourself in utopia, like at college, where professors and friends are readily available to you to offer advice or a helping hand. So, the task of figuring out your life is largely your own.

If you really don’t know what you want to do when you graduate, try to leave as much as wiggle room as possible when looking for your first job. Try to look for jobs that are not so specific but rather involve multiple disciplines. And try to avoid jobs that specifically ask for a long commitment so you don’t get stuck in a position you don’t enjoy. Also, try looking for positions that are more supportive for career development such as internships or jobs in an academic setting.

Keep the learning momentum going.

If you think four years of college passes by so quickly, life after graduation will fly by just as fast, if not faster. Therefore, for those of you who plan to pursue a higher degree after college or move on to a higher-level job, it is important to get yourself prepared before you start wondering where all the time has gone. Don’t treat your gap years as a break, but rather an extension of college. When you have more free time after work or during the weekends, spend some amount of time, even five minutes, studying for whatever tests (such as the GRE) are required for your next stage.

As I also mentioned earlier, your first job might be not as educational as you think it would be. If so, propose some passionate projects to your boss — projects that not only create benefits for your employer but also help you build a competitive background. Because again, once you graduate college, achieving your career goals is very much your own responsibility.

Life after graduation is exciting, and you should look forward to it.

I want to conclude on another important thing that I have learned from this past year. That is, life after graduation is absolutely amazing, regardless of what people say. It’s true that you might have to worry about paying off your bills using your slender income. It’s true that the expectations of you have been switched from student to labor — one being receiver, and the other being provider. It’s true that you still have to work hard after you graduate to help you achieve your next career goal. But at the same time, you will also have more freedom to do whatever you want in life, as no more homework will bug you after business hours. You will have the opportunities to know more people other than your quaint social circle at school. And (alcohol wise) you finally can get to go to happy hours — as a “real” adult — after work with friends and co-workers.

Lives before and after graduation are two parallel worlds, each with their own beauty. So my final advice to you? Do Great Work!

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This article is originally published in the University of Pennsylvania Cell and Molecular Biology Student Newsletter (August 2018).  

EVERY FRIDAY MORNING, Helen C. Davies, a 93-year-old Professor of Microbiology at the University of Pennsylvania Perelman School of Medicine, sets off punctually at 7:45 a.m. to the infectious disease management meeting at the Hospital of the University of Pennsylvania.

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Helen C. Davies, a 93-year-old professor of Microbiology, holding a picture of her from the 1960s.

Helen, who insists people call her by her first name, can’t remember how long she has been attending these meetings. “For a mighty long time,” according to her.

But what she can remember is that she used to be able to walk freely to these meetings -then with a cane. Now, she wheels.

“How are you today, Helen?” greets a senior physician in the elevator concourse.

“I’m good, dear,” she replies, while another physician exits the elevator to make space for her and her wheelchair.

In a meeting room full of white-coated physicians who pride themselves on their career—saving lives, those who have been Helen’s own students are in awe of Helen and her own career—a lifelong educator.

Helen has taught over 10,000 medical students for more than half a century. She has won the annual Excellent in Teaching Award 16 times. And her portrait, which can be found in Johnson Pavilion, was done by Nelson Shanks—whose other commissions include Pope John Paul II, President Ronald Reagan, President Bill Clinton, and Princess Diana.

Despite her innumerable contributions to the university, Helen has never stopped perfecting her teaching. Her infectious disease class, where she sings to students, has helped generations of medical students learn about pathogens in a witty way.

Out of a book full of microbe song sheets she has composed, “Leprosy” is her all-time favorite.

It was written to the tune of The Beatles’ “Yesterday”:

Leprosy,
Bits and pieces falling off of me
But it isn’t the toxicity
It’s just neglect of injury
Suddenly,
I’m not half the man I used to be
Can’t feel anything peripherally
From swollen nerves, hypersensitivity
Why don’t lerpae grow in vitro we cannot say
In vivo they grow very slow, once in 12 days
Hard to get,
But the stigma hasn’t faded yet
Don’t keep an armadillo as a pet,
Don’t forget…


THE DAUGHTER OF A RABBI, Helen was born in Manhattan, New York, in 1925. After growing up in the Great Depression, Helen went to Brooklyn College, where she received her bachelor’s degree in chemistry during World War II. She graduated from college when she was 19, as the only female in her class.

“I never had trouble finding dates back in college, since I was the only girl,” Helen quipped.

Helen received her master’s degree in biochemistry from the University of Rochester in 1950, followed by her doctorate in physical biochemistry from the University of Pennsylvania in 1960.

She has stayed at Penn since then.

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Helen working in her office at University of Pennsylvania Perelman School of Medicine, where she is believed to be the oldest full-time faculty member.

Her husband, Robert E. Davies, a biochemist and a Benjamin Franklin Professor and University Professor at Penn’s veterinary school, died in 1993 while mountain climbing in Scotland.

Soon after her husband’s death, Helen moved into the Quad, living with hundreds of freshmen. “I just love the students so much, I want to be part of them,” Helen says.

Helen is the eldest and the first woman faculty master, the highest administrator on-site, for Ware College House. She leads both the Women in Science and Infectious Disease programs. Her apartment, on the second floor of Ware College House, has two bedrooms and a big living room that Helen adores since “it can host as many students as possible when they come to visit me.”

Like most students in the building, Helen also has a roommate—Emilie Anderson, who graduated from Penn in 2005.

Before her graduation, Emilie came to Helen for advice—she was offered an incredible job opportunity…, but it didn’t pay well. Should she keep looking for other jobs, or take this precious opportunity?

“Helen told me, ‘Sweetheart, if this job is what you love to do, you should take it! Don’t worry about the money. I have a spare bedroom in my apartment, and you can crash with me if that can relieve your financial burden,’” Emilie said. “And I never moved out—it’s been 15 years.”

Like Emilie, many others, especially women and other minorities in the Penn community and beyond, have also been infected by Helen’s love.

Robert Ross, one of the few African American pre-med students on campus in the 1960s, persisted in medicine because of Helen’s constant attention and encouragement. More than two decades later, Dr. Ross has served as the Philadelphia Health Commissioner and is now the CEO and President of the California Endowment, a major health foundation in California.

During the 1970s, Helen taught a 20-week biology course to 20 African American gang leaders as part of the Urban Leadership Training Program, hoping to bring more opportunities to underrepresented communities.

“To talk about Helen without mentioning her contribution to the women and minority communities is just diminishing,” said Susan Weiss, who is also a Professor of Microbiology. “I mean think about it—she marched with Martin Luther King at Selma, during the Civil Rights Movement in the 60s.” Before Dr. Weiss’s arrival in the 1980s, Helen had been the only female faculty member in the Microbiology Department since its establishment in the 1970s.


HELEN NOT ONLY infects people with her passion for her career but also with her love of life.

Just two years ago, at age 91, in her wheelchair, Helen went on a trip with Emilie traversing eight countries, from Southeast Asia to the Middle East, in 20 days.

“Apparently, not only people who know Helen love her, the entire world loves her,” Emilie laughed. “When we were in Burma, I was taking pictures… and I turned around, saw a group of Buddhist monks carrying Helen and her wheelchair all the way up to the top of the monument. And what’s amazing was that they were communicating in languages that neither of them could understand.”

“And when we were in Israel, Helen started chatting with this young, handsome museum guard in Hebrew. And the guard opened the museum just for Helen even though it was closed that day,” Emilie continued laughing.

Only until recent years did Helen start to ease her workload—meaning not leaving for work at 6:00 a.m. and returning home at 11:00 p.m. She now spends most of her day reading in her apartment—sometimes a book a day or sometimes an entire weekly Science Magazine subscription—with the company of “Alexa”, who turns on the lights and plays music for her.

On the weekends, Helen and Emilie Uber to restaurants for lunch, followed by a movie at AMC, just like many students on campus. Or they shop for clothes at thrift stores. They often host parties in their apartment, such as the midnight pancake party, which makes sure “these students would have something in their stomach before getting drunk.”

When asked when she would retire, Helen smiled, “Never.”

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Newsworthy: a novel, implantable robotic sleeve that can support a patient’s failing heart.

Harvard University engineers developed a soft, implantable robotic sleeve that can support heart function for patients suffering from heart failure. The sleeve-shaped robot—designed by Ellen Roche from Harvard University School of Engineering and Applied Sciences and her team—mimics the form and function of a mammalian heart and can be implanted around a failing heart to offer mechanical support. For decades, heart pumps have been used to aid individuals with weakened heart function: the device takes blood from the heart and pumps it to the rest of the body, as a healthy heart would. Patients with implanted heart pumps, however, have been required to take long-term blood-thinning medications to reduce the risk of blood clotting and other complications, due to contact between blood and device surfaces. The advantage of Roche’s team’s design, hence, is that the robotic sleeve does not contact blood, eliminating the need for anti-blood-clotting therapy and reducing the risk of device-associated complications. Also preceding previous efforts in the field, the robotic sleeve, which mimics the outer two layers of the mammalian heart muscle, is able to provide coherent and synchronized assistance to a failing heart. The team tested their robotic design on pig models with acute heart failure, and the assessments have shown promising results. Although further testing for long-term practicality is still indispensible, this robotic sleeve could potentially provide a new approach to help restore people’s compromised heart function in the near future.

Learn more:

“Soft robotic sleeve supports heart function” – Science Translational Medicine  

Related:

“Are blood clots in patients with heart-assist pumps decreasing or on the rise in 2015?” – Science Daily

“Soft robot helps the heart beat” – The Harvard Gazette

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TRANSCRIPT:

HUANJIA ZHANG: Many people in Pennsylvania may have noticed that, nowadays, it is not easy to encounter bats any more at night during the summer. My guest today has spent years working with bats in Pennsylvania, and he will talk to us about the story behind the dramatic declination of bat populations in Pennsylvania.

Mike Scafini is the endangered mammal specialist of the Pennsylvania Game Commission. Mike works with all non-game mammals including everything from bats to Northern Flying Squirrels, Allegheny woodrats, water shrews and other small mammals that people don’t normally think of when it comes to the Pennsylvania wildlife.

Hey Mike, how are you today?

MIKE SCAFINI: Pretty good, how are you doing?

HUANJIA ZHANG: I am good, thank you! Thanks for joining me today.

So, at the beginning at the talk, I want to start with “misunderstanding”. Perhaps, no other mammals in the Northeast are as misunderstood as bats. Because of their dark, small, flying and nocturnal features, bats, unfortunately, have been considered vicious animals that bite and can carry diseases. Could you please tell us whether these rumors about bats are true?

MIKE SCAFINI: Well… yea, there are a lot of misconceptions about bats. From you know all the horror movies you see, and the things you see on the news. But actually up close, bats are pretty cute. You mentioned drinking blood, that’s vampire bats, that’s central and South America.

We owe a lot to bats, they are the only predators of night flying insects. I have seen a lot of different figures saying bats can eat 45 insects in a single evening, which equals to a million insects in an entire year. So, the agriculture industry in PA owes a lot to bats. They eat your crop pests and they eat all your nuisance pests like flies and mosquitos that people don’t want around the summer time and so yea… we owe a lot to bats and they are really not scary once you see what they are all about and see them up close.

HUANJIA ZHANG: There are nine species of bats commonly living in Pennsylvania. Among the nine species of bats, six of them, which include the little brown bat, big brown bat, eastern pipistrelle bat, northern long-eared bat, Indiana bat, and eastern small-footed bat, are short distance hibernating bats, meaning that they don’t make long migratory trips when winter comes. Instead, they will hibernate in Pennsylvania or in adjacent states. The rest of our bat species, which are silver-haired bat, eastern red bat, and hoary bat, in contrast, will migrate to the south when winter approaches, some birds.

The population of hibernating bats in Pennsylvania, has dramatically declined over the past decade.

MIKE SCAFINI: Back to the six species again, we have three of them; well actually four of them; are actually 99% declined.

HUANJIA ZHANG: The terrible drop in hibernating bats in Pennsylvania, and along the entire east coast of North America is primarily caused by a new bat disease called white nose syndrome.

MIKE SCAFINI: White nose is a bat that’s been infected with Pseudogymnoascus destructans, which is a fungus and it’s believed to be transferred from Europe. It is proposed that it came from humans that went caving to Europe and brought it back to New York State. And since then, it spread up and down the east cost and moved its way westward even up into Canada. Bats that get infected with this fungus, it irritates them when they are hibernating. So, they become dehydrated, they wake up more often, and oftentimes they will fly out in the middle of winter when it’s cold and there is no insects to eat and that’s primarily the cause of all these deaths.

I have a figure here in front me that shows our hibernacula surveys: it compared those sites that we checked before white nose and we also have surveys after white nose in PA. So each year, we survey more sites, each winter. And so we have more sites to compare with the pre-white nose years. And each year four of our species: little brown, Indiana, long-eared, and tri-colored have really not rebounded. Their numbers, for examples, we have Altenburg County in central part of the PA; we have a site called canoe-creek mine. It had at one point hit a high of 34,000 bats, and now we are at between 70 and 80 total.

HUANJIA ZHANG: Unfortunately, there is no cure for white nose syndrome for bats right now, but scientists are working hard to find the cure.

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Mike Scafini, an endangered mammal specialist of the PA Game Commission, is descending into a cave to conduct a bat survey.

MIKE SCAFINI: There is actually; we had an interesting experiment that’s worth mentioning. There are kinda two different things and I will tell you the one we are more involved with—it’s called PEG 8000, Polyethalglyco 8000. I guess it’s found in the pharmaceutical community a lot. It’s what it does is to trick the fungi into thinking its water stressed, so it doesn’t grow. And we kinda set up an experiment with three cages, seven bats in each cage. One was control, one had this PEG 8000 applied to one of their wings and the other one had the PEG applied to the roost itself on the wall. And what we saw was the one that we applied to the wing it didn’t make any difference, it still got the PD fungus, it didn’t have any effect. And the one we applied to the roost, they were fine; they didn’t pick up the spore. So, we were thinking the PEG 8000 could be almost a roost cleaning application. It would be near impossible to treat a whole cave, but being that bats are creature of habits, they go back to some of the same spots in the cave. So if we could treat maybe the main spots where they go each winter, where they all congregate together, we may have beyond something as first.

HUANJIA ZHANG: So far we have talked about the decline of hibernating bats, what about the non-hibernating bats? Are they also being threatened?

MIKE SCAFINI: We also have the migratory bats, and they are being hit by wind farms. That’s part of what I did my graduate work on. There is a wind farm in Schuylkill county where I did what they called post-construction mortality surveys. And just an estimate of a roughly 12/13 turbine wind farm is killing 500 or more bats every summer. So, there have been different ideas of why that is: they are following the top where they think that the turbine is a tree to roost on. But so far, they haven’t come up with…they come up with some ways to help slow the turbine blades when wind speeds are low, which is when bats typically fly, and the turbine isn’t creating that much of energy anyway. So they come up with some different way to curtail the impact, but between white nose for the hibernating bats and turbines for migratory bats, and then just the normal fact that bats are really slow reproducers—most of their species only have one pup per year. Big browns and red bats can have two, but for the most part, with this kind of decline it is hard for them to rebound. Just from natural death and all these other factors, that’s been a pretty steady decline.

HUANJIA ZHANG: Sometimes bats come into our backyards or into the house. What should people do if bats visit their home?

MIKE SCAFINI: The bats in homes is something that we more see as a problem in the summer. I get emails left and right in the summer time: people that have bats in their homes and they want them out, or bats in their barn. Essentially, bats form maternity colonies in the summer to raise their pups, so, when it’s the hottest months of the year, that’s when females are with their pups—June and July. When you see them in your home, there are different things that you can do. One option is to call us and we can try to direct you to someone—cuz we can’t really response to all calls, we can kinda guide you through the process—we can it eviction and exclusion. Eviction is where you put a one-way door, say, if you know where the opening is, if they are coming into your attic, there will be a door where they can fly out but not back in. The only problem with that is you can’t do it when there are flyless pups. So, like I said, they are forming maternity colonies. So, there is a window time in the middle of the summer that this won’t work—you’ll be trapping bats inside and the adults fly out to feed the pups are gonna try whatever they will to get back in, but otherwise, it’s a really good technique—once all the bats fly through that door, you can the seal any openings.

HUANJIA ZHANG: As Pennsylvania residents, we are constantly hearing depressing stories of endangered or threatened wildlife and diseases that affect bats. What do you think are things we can do here in central PA to help protect bat populations?

MIKE SCAFINI: Some of the big things that you can do, hum, the one like I mentioned is the Appalachian bat count. That gives us a handle on not only where the bats are, a good majority of the year during the summer, but also if they are reproducing. Because the ABC counts are designed to count before and after they (bats) have their pups. So, we can actually see how much they are reproducing. So, kinda give us this idea in the handle on bat populations, where they are, that’s probably the biggest that they can do, is participating that program.

Opening/ending Song:

Leaving Song by Barefoot McCoy

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IT WAS AN UNSEASONABLY WARM DAY in late February. Hibernating squirrels were out looking for food. Birds, too, began to twitter on the telephone wires. I, zig-zagging along the narrow central Pennsylvanian country roads, was driving to meet up with Mike Scafini, an endangered mammal specialist for the Pennsylvania Game Commission, to talk about Pennsylvania’s vanishing bats.

Mike greeted me as soon as I walked through the automatic door of the Pennsylvania Game Commission building.

“How are you today?” he asked, while giving me a sturdy handshake.

Mike—a tall, slim, 30-some-year-old fella with a thick dark beard, short hair, and a pair of thin-wire glasses—is a wildlife biologist for the PA Game Commission. His job is to manage all non-game mammals, such as northern flying squirrels, woodrats, and of course, bats, across the Commonwealth of Pennsylvania.

The Game Commission compound itself is interesting. Sitting on the outskirts of the state capital, Harrisburg, the exterior resembles something between a DMV building and a middle school auditorium. The inside, however, is an eerily harmonious combination of a natural history museum, a country pub, and the visitor center of a national park: green carpet, wooden benches, deer heads mounted on the wall, various wildlife taxidermy staged in giant glass cabinets, a canoe in the center of the lobby, a TV showing animal videos on loop, and exhibitions displaying law enforcement officer uniforms.

“When people think of the Game Commission,” Mike told me, “they usually think of elk or deer or bear; but here [at the Game Commission], we are actually also in charge of small mammals that people don’t usually think of as Pennsylvania wildlife.”

“That’s why I am here today: to talk to you about bats,” I agreed that most people I know had little awareness of these small creatures in their local environment.


THERE ARE NINE SPECIES OF BATS found in Pennsylvania: little brown bat, big brown bat, eastern pipistrelle bat, northern long-eared bat, Indiana bat, eastern small-footed bat, silver-haired bat, eastern red bat, and hoary bat.

Among the nine species of bats, silver-haired, red, and hoary bats are migratory bats, meaning they—like some birds in North America—migrate to the south when winter approaches. The rest of the species are short-distance hibernating bats, meaning they don’t make long migratory trips when winter comes. Instead, they hibernate in Pennsylvania or in adjacent states.

The most common species in Pennsylvania nowadays, according to Mike, is the big brown bat.  When a person sees a bat in Pennsylvania, it is most likely the big brown bat.

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For states like Pennsylvania, which depend heavily on agriculture, bats are extremely important for the economy. Bats are the state’s primary night-flying predator of insects, protecting people and agriculture from pests. Some research shows that a single bat can forage as many as 500 insects in an hour, which equals  3,000 insects every night. A colony of 150 big brown bats, the most common bat species in Pennsylvania, can consume approximately  38,000 cucumber beetles, 16,000 June bugs, 19,000 stinkbugs, and 50,000 leafhoppers. And by devouring the adult beetles, bats can also prevent 18 million corn rootworms from hatching in a single summer.

“The Pennsylvania agriculture industry owes a lot to bats,” said Mike, while pointing at a figure from a 2011 study published in Science. The figure was captioned: “Estimated economic value of bats to Pennsylvania farmers…Bats can save farmers $74 per acre—and millions of dollars each year—by eating bugs that can ruin a harvest.”


THE DESTINY OF HIBERNATING BATS in Pennsylvania, like the destiny of their peers across the east side of North America, has become catastrophic, because of a newly discovered bat disease called White-nose Syndrome.

Since its first discovery in the U.S. in February 2006, White-nose Syndrome has spread rapidly across the eastern states and provinces of the United States and Canada, wiping out millions of hibernating bat population. The first sign of White-nose Syndrome in Pennsylvania was recorded around the winter of 2008, and since then, the population of hibernating bats in Pennsylvania has been dramatically declining.

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Tri-colored bat with visible signs of WNS from Cumberland Gap National Historic Park. Photo from U.S. Fish and Wildlife Service

“Of the six [hibernating] species [common in Pennsylvania],” Mike explained, “we have four of them close to, or approaching, ninety-nine percent [declination].”

“Jeez…ninety-nine percent?” I couldn’t believe what I had just heard.

“Yes…it’s a lot of bats.” Mike shook his head.

He went on to show me another figure from surveys he conducted by comparing the winter bat species population at the same sites in 2013 and 2016, which were before and after the White-nose Syndrome outbreak. In the graph, the populations of little brown, Indiana, northern long-eared, and tri-colored bats have declined almost one hundred percent.

“And the number of bats has not rebounded,” Mike added.


THE FUNGUS THAT CAUSES White-nose Syndrome in bats is called Pseudogymnoascus destructans, a cold-loving fungus that can infect and colonize the bats’ skin. This fungus is native to Europe but not to North America. Scientists have speculated that cavers who went to Europe for caving brought this fungus back and inoculated this invasive pathogen into the caves in New York State.

During hibernation, bats reduce their metabolic rate and lower their body temperature to save energy, which offers the opportunity for the fungus to live, grow, and reproduce. Bats infected with white-nose syndrome often have visible white fungal growth on their muzzles and wings (hence the name) and become irritated and dehydrated. As a result, they wake up and fly out more often during the cold winter while there are no insects to eat. And this has become the primary cause of death for bats infected with White-nose Syndrome.

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Scanning electron micrograph of G. destructans culture isolated from a Little Brown Bat. Photo by Deborah J. Springer

Despite the fact that scientists have been working around the clock to find a cure for White-nose Syndrome in bats, the remedy still remains a mystery. Nevertheless, there is some hope in promising treatment, which was recently discovered by scientists and might be able to end this disease for bats.

“There is actually an interesting experiment that is worth mentioning,” Mike said. “It’s called PEG-8000.”

PEG stands for polyethylene glycol, and it is a class of chemical compounds that have a wide range of medical, chemical, biological, and industrial uses. PEG-8000 is one specific type of PEG that can cause microbes to think that they are deficient of water, thus tricking them into slowing growth. Plus, because PEG-8000 is non-toxic and chemically stable in fungi, it is considered as an ideal compound to stop White-nose Syndrome by hindering the growth of Pseudogymnoascus destructans—the fungus that causes White-nose Syndrome. Based on what Mike described, when scientists applied PEG-8000 to the wall of the roost, bats in the experiment were able to avoid picking up the Pseudogymnoascus destructans spores.

“This indicates PEG-8000 could be used as a roost cleaning application,” Mike explained. “And being that bats are creatures of habit—they go back to the same spots in a cave in the winter. If we can treat these spots where bats congregate, we may have something.”


THE SPREAD OF WHTE-NOSE SYNDROME can be caused by physical contact between healthy bats and infected bats, or by bats picking up the fungus from the surface of the cave where they hibernate. Human activities in the caves have exacerbated the spread the disease by introducing the fungus from one cave to another or by inadvertently carrying the fungus on shoes, clothing, or gear. (Just like the fungus is believed to have been introduced to North America to begin with.)

Therefore, Pennsylvania government agencies, such as the Game Commission, have strictly implemented the decontamination protocols released by the U.S. Fish and Wildlife Service to minimize their chance of spreading white-nose syndrome among bats when working in the field.

“We are working closely with the U.S. Fish and Wildlife Service, and one big step was the decontamination protocol that [the U.S. Fish and Wildlife Service] put out,” Mike explained.

Therefore, PA government agencies such as the PA Game Commission has also strictly implemented decontamination protocols released by the U.S. Fish and Wildlife Service to minimize their chance of spreading white-nose syndrome among bats when working in the field.

According to the newest (2016) version National White-Nose Syndrome Decontamination Protocol, individuals in contact with bats or going into the hibernacula of bats are recommended to decontaminate their gear—an effective way to prevent the spread of the spores of the fungus. These procedures are strictly followed by bat survey participants like Mike and many other scientists from the state government agencies.

In addition to the state level of protection, the Game Commission is also working closely with the caving community throughout Pennsylvania to raise their awareness of which caves people should go into and which they should avoid, as well as implementing the decontamination guidelines to the caving community.

“Most [caving] people don’t have any problems following the decontamination protocol,” Mike said. “Some caving groups are actually helping save the bats by helping conduct bat surveys.”

To survey the bat population, every winter, Mike, along with other bat scientists, often enter dozens of sites where bats are hibernating to count their population.

“[The caving groups] often count the bats while caving and report the data to us.” Mike went on. “Sometimes we even invite them to come into the cave and help us out for the survey.”

“Do you consider yourself a good caver?” I asked Mike.

“I’d say so.” He laughed.


WHILE HIBERNATING BATS have been suffering from white-nose syndrome, migratory bats are also not without threat. They are declining because of a different threat: wind farms.

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Bat killed by collision with wind turbine. Photo by Tomaž Jančar

According to Mike’s survey, a thirteen-turbine wind farm can estimably kill five hundred or more bats every summer. Mike spent part of his master’s work in biology on surveying the effects of wind turbines on migratory bats.

“Altogether—the wind farms for migratory bats and White-nose [Syndrome] for hibernating bats—are dramatically wiping out the PA bat population,” he added.

Mike’s concerns are important to consider as the United States is now one of the world’s leading producers of wind energy. Although wind energy is often considered “good” energy for us, it might not be as “good” for flying animals. With tens of thousands of wind turbines operating in the U.S. currently, and a great number planned to be constructed, the death of flying animals—not only bats, but also birds—has been increasing every year. According to the American Bird Conservancy, the annual mortality of birds caused by wind turbines was estimated to be as high as 573,000 in 2012. The U.S. Department of Energy predicts if the U.S. meets its goal of 35% of the electrical power from wind energy, up to five million birds would be killed annually by the wind turbines.


“SO, WHAT CAN WE DO to save bats when they visit our homes?” I asked, citing a problem many people may have encountered.

Bats in homes is something we see more as a problem in the summer, answered Mike. This is because bats form maternity colonies during the summer to raise their pups. In some cases, bats will try to set up a colony in people’s attic or other warm, dark places.

When a single bat invades a home, people can wait for the bat to land on something and then catching the bat by putting a Tupperware over it while slicing a piece of cardboard underneath the bat. The caught bat can be released onto a tree.

“If it is a larger number of bats,” Mike continued. “We have what is called NWCO, which is Nuisance Wildlife Control Operators…they know how to deal with bats.”

Additionally, people can practice “eviction and exclusion“, where they can put a one-way door in the opening of the house, so that bats can fly out the house but not back in. Once all the bats fly out, people can seal the openings. However, Mike also warned, this option won’t work if there are flight-less pups in the colony since “the adult bats will try whatever way to get back to the pups.”


Time flew by quickly, and, unwittingly, I had already spent hours talking with Mike. As I got ready to leave, I asked Mike what was the most unforgettable moment in his career as a bat scientist. His answer was the “good old days” when he could descend into a cave during a winter survey and see thousands and thousands of bats. 

“That’s what it used to be like at the larger sites here in Pennsylvania.” He said while walking me out of the Game Commission building. 

Driving on the same zig-zagging Pennsylvanian country road, I couldn’t help but ponder how after Mike showed me all the figures about bats that he had prepared for this interview, he said, “ Yup… everything is going down…”


1 Data from Wildlife Outreach Center, Penn State Extension. http://extension.psu.edu/natural-resources/wildlife/wildlife-nuisance-and-damage/bats/a-homeowners-guide-to-northeastern-bats-and-bat-problems

Realated—if you enjoy this article, you may also like these 

Bat Conservation International: http://www.batcon.org

Bird-smart Wind Energy: Protecting Birds from Poorly-Sited Wind Turbines: https://abcbirds.org/program/wind-energy/

PennState Extension-Wildlife Nuisance and Damage-Bats: http://extension.psu.edu/natural-resources/wildlife/wildlife-nuisance-and-damage/bats/wildlife-damage-control-4-bats

Using a Novel Partitivirus in Pseudogymnoascus destructans to Understand the Epidemiology of White-Nose Syndrome: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5189944/

National White-Nose Syndrome Decontamination Protocol – Version 04.12.2016: https://www.whitenosesyndrome.org/sites/default/files/resource/national_wns_decon_protocol_04.12.2016.pdf

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I HAVE TO ADMIT, before I start writing about bats, the last time I spent hours at night paying attention to a “bat” was me watching Batman vs. Superman while swallowing coke and popcorn.

I used to think I know bats well—I know they are mammals, I know they can fly, I know (at least to me) they look like mice, with wings, and I know they are mostly active at night. However, as I start to learn more about bats, I come to the conclusion that I don’t know them well.

Maybe, I realize, I am not the only one who doesn’t know much about bats. Therefore, in this post, I want to share with you something interesting about bats—something I used not to know about bats; something that, over the years, I have wondered about bats but never had time to find out. And, of course, I want to tell you more about my “Bat-Man Project”.

Bats are the only mammals that can fly.

Hereby “fly”, I mean the true, naturally sustained flight—not squirrels “flying” from one tree to another, not cats “flying” from balcony to the backyard, not the Wright brothers “flying” in their revolutionary flying machine four miles south of Kitty Hawk in North Carolina. You might think bats have the same wings as birds’. In some sense, yes—they both have flattened forelimbs that form wings. However, unlike birds whose entire forelimbs are flattened to become wings, bats have evolved with only flattened hands. No wonder the scientists who know ancient Greek give bats such a catchy scientific name—“chiroptera,” meaning hand-wing. The fingers of bats are extremely long and spread-out and are covered with a thin membrane, forming a light, elastic, and strong webbed wings. Having the ability to fly means bats can enjoy the slice of pie in the food web that most mammals can’t share—the flying insects. So, next time you say, “early bird gets the food,” also keep in mind “flying bat” gets the food too!

Bats are the second largest order of mammals in the world.

Underrepresented by humans, bats are not a minority species. After rodents, bats are the largest order of mammals. Scientists have identified more than 1,300 species of bats1, which represents roughly twenty percent of all mammals species in the world. Of all the bat species, they can be roughly categorized into two types. One is the large fruit-eating megabats also known as the flying fox (another illustration of scientists’ rich imagination when naming species). The other type of bat is the much smaller microbat. Microbats feed on insects and have the echolocating ability—the ability to use sound to detect the environment, which their siblings, flying fox bats, lack.

Bats have been misunderstood by people.

Are bats really as wicked as people rumor? Or do bats really eat people? The truth is, they do not! No other mammals are as misjudged by humans as bats. Seventy percent of the bats in the world are exclusively insect-eaters, while the rest of them are mostly fruit-eaters. Only a few species of bats—such as fish-eating bats, which feed on fish, or vampire bats, which feed on blood—eat animals other than insects, and these bats are primarily distributed in South America. So, what is the chance of you being attacked by a bat? Probably the same as being attacked by your neighbor’s puppy—which is pretty low. And what is the chance of your blood being sucked by a bat? As rare as you winning the one-million-dollar Powerball, especially if you live in North America.

Bats are extremely beneficial for us.

All the bats that inhabit the United States are microbats that ONLY live on insects. With that said, bats make good neighbors! They, as the primary predator for night-flying insects, majestically forage for insects that humans find problematic. Such as, June bugs that tear apart tree leaves, cucumber beetles that harm our cucumbers and muskmelons crops, stinkbugs that pierce the skin of fruits, mosquitos that suck out your and your animals’ blood, and countless other harmful pests to our agriculture and health. The important role bats play in insect control is exactly what makes bats important for our agriculture and the ecosystem.

Bats are seriously threatened.

Despite being beneficial to our ecosystem, bats are at risk from humans. The population of bats is declining globally because of severe disruption to bat habitats—26 bat species have been listed “Critically Endangered” by the International Union for the Conservation of Nature (IUCN), meaning they face the imminent threat of extinction in wild1. Along with these “Critically Endangered” bat species are fifty-one others that are “Endangered”, and with 954 bat species that are considered “Vulnerable”1. That’s (26 + 51 + 954)/1240 = 83%! More than eighty percent of the entire bat species are being threatened!

Here in North America, the bat population has dropped drastically because of white-nose syndrome (WNS), a bat disease caused by a European-origin fungus named Pseudogymnoascus destructans. In Latin, “Destructans” means “destroying”, and as its name indicates, this fungus has been destroying the bat population harshly. Since the first discovery of WNS in Upstate New York in February 2006, WNS has spread across the eastern part of the U.S. and Canada, wiping out over 5.7 million of the bat population in North America1. The cure for WNS is still a mystery.

And Finally…About my “Bat-Man Project”. 

The public’s lack of information about bats propelled me to start this Bat-Man project. By studying, researching, and writing about bats, I want to educate people on the social, cultural, and historical aspects about bats, as well as the interesting science behind bats. Most importantly, I want all of us to help save bats. I hope many of you, after reading my blogs, can assuredly tell your friends that bats won’t attack them, can calmly handle a bat when she visits your home, can tell people the fun fact that only Chinese culture is believed to associate bats with good luck among all cultures in the world. And can, if you want, spend a weekend afternoon teaching your children how to build a bat house and hang one in your backyard.

After all, we are the people who must save the bat!

Here’s to the bats!

Data from Bat Conservation International 

Explore More:

Bat Conservation International 

Penn State Extension – Wildlife Outreach Center – Bats

Penn State Extension – Wildlife Outreach Center – A Homeowner’s Guide to Northeastern Bats and Bat Problems.

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Driving his decrepit red Ford pick-up truck on a narrow country road that winds through farms, hills, and creeks, Dr. Ryan Kerney finally takes Liz and I to Michaux State Forest, on a chilly spring day. Here, thirteen miles west of Gettysburg, PA, is where we are authorized to collect spotted salamander embryos under a Pennsylvania state permit.

Michaux State Forest, of course, is not the only place to find spotted salamanders embryos. If you live in New Brunswick, Nova Scotia, Ontario, Québec of Canada, or Alabama, Arkansas, Connecticut, Georgia, Illinois, Indiana, Kentucky, Louisiana, Maine, Maryland, Massachusetts, Michigan, Mississippi, Missouri, New Hampshire, New York, North Carolina, Ohio, Oklahoma, Pennsylvania, Rhode Island, South Carolina, Tennessee, Texas, Vermont, Virginia, West Virginia, Wisconsin of America (It’s a long list…isn’t it?), chances are you could easily encounter spotted salamander embryos in a local pond after the first warm rain in the spring.

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Egg mass of spotted salamander: they can easily be found in ponds during the spring across the East Coast of the United States.

Surrounded by their egg capsules, these tiny dark spotted salamander embryos look like marble beads garnished with green glitters. Outside the egg capsules is a thick layer of jelly coat, forming a big egg mass amid the vegetation in water. “Deep inside these egg masses, there are cells that are interacting between the world of algae and the world of salamander,” says my mentor Dr. Kerney, Associate Professor of Biology at Gettysburg College, who is also known as the “salamander guy” for his dedication of salamander studies.

It takes two to tango

The association between spotted salamander embryos and green algae is first discovered by naturalist-scientist Henry Orr in 1888. Orr’s discovery offers a great demonstration of a mutualistic symbiosis—the harmonious living together of two species: algae provides oxygen to salamander host by photosynthesis, while the salamander offers nitrogen-rich waste products to the algae as nutrients. According to our collaborator Dr. John A. Burns, postdoctoral researcher in the Division of Invertebrate Zoology at American Museum of Natural History, the symbiosis between algae and spotted salamander is more than beneficial but rather necessary.

“Salamander embryos tend to be smaller and have a lower chance of survival if the algae stops supplying oxygen by photosynthesis or if the algae is taken away from the salamander,” says Burns.

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Spotted salamander embryo observed under fluorescent microscope: right dots shown are the light emitted by algae under fluorescent light.

Questions, however, arise around how these beneficial algae get through the thick jelly surrounding the embryos, and how these algae can break through the egg capsule that further protects the salamander embryos from the environment? To answer these questions, Kerney decides to observe these salamander embryos under a microscope to find some hints. Fortunately, the photosynthetic property of algae offers some convenience to be easily observed—because algae are photosynthetic, if you shine one wavelength of light on them, they will emit another wavelength of light back, making them easily to be observed under a fluorescent microscope (microscope that can emit certain wavelength of fluorescent light to the object).

The High-Five Moment

The high-five moment comes when Kerney observed the salamander embryos under fluorescent microscope.

“ I looked at a later stage of embryo with a fluorescent microscope to see if there is any sign of algae persisting near the time of hatching,” Kerney says, “and it was totally surprising to see there is algal cells embedded inside the embryo itself.”

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Transmission electron microscope of a spotted salamander cell containing endosymbiotic algal cells.

To further investigate what is happening between the salamander embryo and algae, Kerney takes a step further by observing the specimen under a transmission electron microscope, a microscope that have high enough resolution and can magnify objects for 10,000,000 times. Seeing the image from the electron microscope, he realizes he have just discovered something totally unexpected and astonishing: the algal cells not only live around salamanders, but also they go inside the individual cells of the salamander embryo. Indeed, this cell living within a cell relationship, which scientists refer to as “endosymbiosis” that occurs between algae and spotted salamander embryo—like a Russian matryoshka doll—is the first known example of a symbiont entering into the host cells of a vertebrate.

A Learning Process

After the exciting moment of revealing the first known example of vertebrate endosymbiosis between algae and spotted salamander, more questions regarding this unique intimate relationships are apparent.

“The question that we are currently tackling is what kind of molecular change is happening when these salamander and green algal cells are together,” says Dr. Eunsoo Kim, who the assistant curator of microbial diversity and systematics in the Division of Invertebrate Zoology in American Natural History, and our collaborator.

To unveil the molecular changes that may lead to this unique phenomenon, Kerney, Liz and I decide to compared messenger RNA (the middle-step information code between DNA and protein) from four different groups of cells: salamander cells with algae endosymbiont, salamander cells without algae edosymbiont, algal cells live within salamander host, and algal cells outside the salamander hosts. Our goal is to discover the differences of gene expression for both algal and salamander cells when they have come together.

Explanations to this unique endosymbiosis relationship start to emerge with more and more investigations being done. We have recently discovered that both the algae and the salamander have changed their gene expressions (segments of DNA that encodes useful genetic information) in order to adapt to each other. Genes that are responsible for importing inorganic nutrients for algal cells, for instances, have been turned off when algal cells are inside the salamander cells, since inside the salamander cells, there are enough organic nutrients for algae. (Will you still do grocery shopping if there is already enough food for you?)

Uncovering the bigger secrets

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Like how spotted salamanders are closely associated with microbes, humans also have trillions of microbes (called microbiome) living on and inside our bodies. Illustration from American Natural History Museum.

“We are learning that the algal cells and salamander cells are dramatically changing each other to adopt each other,” says Kim. “This change may be relevant for other symbiotic systems including human and parasitic bacteria relationships.”

We, as humans, also have trillions of microorganisms living in or on or bodies. Therefore, based on our investigations on spotted salamanders and their algal symbionts, we are also hoping to shed light on the secrets behind how human microbes interact with their human host—us—and alter our physiology.

One afternoon in the forest, dressing in the waders and trekking through the cold, muddy ponds, we have collected enough embryos for the next round of experiment. With exhaustion, I, once again, find myself on Kerney’s decrepit red Ford pick-up truck zig-zagging along the narrow country road that leads us back to town.

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Newsworthy: previous dietary experience and gut microbial exchange with other individuals have implications on affecting a person’s response to new diets. 

EATING HEALTHILY is at the top of the list for many of those setting New Year’s resolutions. However, changing your diet could be more complicated than you think—researchers have found that your previous dining experience could impact your new diet efficiency through gut microbiota. This might explain why so many New Year diets don’t work.

Gut Microbiota: Our Native Flora by Micah Lidberg

But hold on… researchers also found that if there’s another person in your household who already eats healthily, you might have a better chance of
success. The reason might be that their gut microbes are influencing your dietary practices, according to a recent study published in Cell Host & Microbe. The implications suggest possibilities in developing probiotics that simulate a similar healthy gut microbiota community to support your dietary changes.

The study conducted by Dr. Jeffery I. Gordon, director of the Center for Genome Sciences & Systems Biology at Washington University in St. Louis and his team, was interested in if and how, gut microbiota—the tens of trillions of microorganisms in our intestine—affect, and are affected by, our dietary practices. These tiny microbes usually live happily within our gut and pay the “rent” to our body by helping digest food and synthesize essential vitamins such as vitamin B and K. Gut microbiota also function as an armor for our intestine to defend against other aggressive microorganisms.

Previous studies suggest that typical unrestrictive American diets might result in a weakened gut microbiota, which can compromise overall health. To put this idea to the test, Dr. Gordon and his colleagues genetically analyzed fecal samples from 34 adult donors who have maintained healthy diets and 198 donors who have typical unrestrictive American diets. The results indicated that people who practice healthy diets bear a significantly richer and more diverse gut microbiota than people who do not, including many microbes that seem to only be associated with a healthy diet.

Dr. Gordon’s team also found that when transferring the fecal microbiota from the unrestricted-diet individuals to germ-free mice, these mice were not able to adjust to a new diet as easily as their counterparts, who were received healthy-diet microbiota. Based on these results, the researchers suggest that reduced bacterial diversity caused by the prior dietary practice can influence our body’s response to a new diet.

However, there is still hope in the story of gut microbiota. Although each of us has our unique collection of gut microbiota, it is never isolated or static. Instead, we are constantly shedding our microbiota—picture that we are all surrounded by a cloud of our microbes. Our microbiota and other individuals’ microbiota come together and make up a large microbial community called a metacommunity. Within the metacommunity, we continuously exchange our microbes with people who live in close association with us.

In a follow-up experiment, Dr. Gordon and his colleagues created an artificial metacommunity by placing together mice harboring unrestricted-diet microbiota and mice with healthy-diet microbiota to further understand whether promoting bacterial dispersal between these mice could affect their responses to diet change. Interestingly, it turned out that mice with unrestricted-diet microbiota, which previously showed inefficient response to the new diet, have significantly improved their digestive performance by being in close proximity to mice with healthy-diet microbiota.

These findings suggest important implications for how dietary practices can be prescribed for success. However, since this study was primarily on mice, it will take more research to determine the health outcomes of the interpersonal microbiota exchanges for humans. The researchers believe that with a richer understanding of how humans exchange microbiota with other individuals and its effects on health, one day our concept of “social” diseases will be refreshed to incorporate perspectives of metacommunity dynamics in public health.

For many people, switching a diet can be challenging. Therefore, uncovering microbial potentials and ensuring a positive response to new diets for our body have always been a major goal of these studies. The hope in the near future is to be able to identify microbes that are associated with different dietary practices and use these microbes to make probiotic products in order to enhance people’s digestive responses to their new diet.

After all, switching to a healthy diet is always a smart choice for your health!

Related:

It’s Not Yet Clear How to Boost the Microbiome. But Diet Is the Best Bet” – TIME

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“So, what is this General Tso’s Chicken?”

“It’s hard to explain… It’s a sweet, Americanized dish made out of chicken. Americans love it.

Above was the conversation I had with the owner of the first Chinese restaurant I stepped into in the United States. After arriving to a small town in central Pennsylvania for college, I decided to visit one of the few Chinese restaurants in town hoping to get some food that would ease my feelings of being homesick. Unfortunately, not only did I get little comfort from the authenticity of the food, I became even more jumbled by what appeared on the menu. Why on earth does General Tso, this national hero I learned about in high school history books, have anything to do with chicken?

Perhaps, even General Tso himself would not have expected that one day his name would become famous all the way across the Pacific Ocean—but not for his battle achievements, rather for a chicken dish.

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General Zuo Zongtang (1812 – 1885), often known as General Tso, was a famous Chinese military leader and statesmen of the late Qing Dynasty.

Best known as a nineteenth-century general, politician, and national hero to Chinese people, General Tso’s full name is Zuo Zongtang (Tso Tsung-t’ang was the transliteration of his name before the standard Chinese phonetic system came out). He was born in 1812 in Hunan province, a region in southwest China that is famous for its spicy food and its people’s firey military tradition. As a formidable general, Tso led many successful battles to defeat rebel groups on the northwest border. His most famous achievement was recapturing the Xinjiang region from the Uyghur rebellions. After serving the Qing Dynasty for his entire military career, General Tso died in 1885, leaving his legendry stories to be shared and passed down from generation to generation.

So, how did General Tso end up entitling a chicken dish? The roots can be traced back to a famous chef named Peng Chang-kuei, who came from the same region as General Tso. Born in 1919, Peng grew up in a deprived family during the most troubled times in contemporary China. As a teen, Peng served as apprentice to Cao Jingchen, who was a private chef for the Nationalist officials and the owner of a famous restaurant. After years of apprenticeship, Peng became a famous chef himself and his cooking was so exceptional that he became the executive chef for the Nationalist government banquets.

In 1949, the Chinese civil war broke out, during which the Communist army defeated the Nationalist government. When the Nationalist party fled to Taiwan, many service people were brought with them, and among them was Peng. In Taiwan, Peng continued serving the Nationalist government as a chef and soon opened his own restaurant “Peng’s Huanan Yuan”—the most famous Hunan-style restaurant at the time. In his restaurant, Peng created many dishes that were inspired by his much-missed hometown and reflected Human cuisine. One of them includes General Tso’s chicken—a heavily sour, salty, and spicy chicken named after one of Hunanese favorite historical figures General Tso.

The “General” did not arrive in the U. S. until the early 1970s when America’s first Hunanese restaurant, “Hunan,” opened in Manhattan, New York. Inspired by Peng’s General Tso’s chicken in Taiwan, chef T. T. Wang, of the Hunan restaurant, also devised a dish called General Tso’s chicken with more American flavor and introduced this dish on the menu. With the huge success of Hunan restaurant, General Tso’s chicken—this fried, buttery and sweet chicken dish that fits American people’s tastes all around—soon got its own reputation. Shortly afterwards, it was copied by other Chinese restaurants all over the country, making General Tso’s chicken one of America’s favorite Chinese dishes.

Today, you can find General Tso’s chicken almost anywhere in this country. In fact, because of this dish, General Tso has become one of the most famous Chinese people known by the American public, of similar fame to Yao Ming or Jackie Chen. Ironically, although most American people have ordered meals in his name countless times, few of them know who General Tso really was, and why this dish was named after him. People always joke that General Tso to Americans is like Colonel Harland Sanders to Chinese—people know them because of the chicken, but not so much as military officers.

Meanwhile, on the other side of the world, despite the fact that General Tso’s chicken was first invented in Taiwan, it never become as popular as it in the U.S.. In fact, most Chinese people have never heard of it or tasted it. General Tso is still commemorated by the Chinese people as the celebrated Qing general. Even though General Tso’s chicken is as exotic to the Chinese as it to Americans, it is still widely considered to be a Chinese dish. After all, it embodies the history of civil war, the sentimental attachment of homeland, and the struggle of early Chinese immigrants to adapt to American society. Just like how General Tso’s Chicken is rich in flavor, this dish is also rich in its cultural connotations.

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R.V., Chemicals, science equipment, blue gloves, and a busy lab crew…, for many “Breaking Bad” fans, this scene sounds oddly familiar. Believe or not, this was how Kerney lab as well as Kerney lab’s collaborator  spent their 2015 spring break. Unlike the characters of “Breaking Bad”, we were not making drugs, but participating in our “west meats the east” co-culture research experiment.

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Walking through the ancient forest is like Alice exploring her wonderland – so much unknown excitement!

Launched by Dr. Ryan Kerney and Jasper Leavitt ’15, this co-culture experiment aims to study what will happen if we swap the algae from Northwest salamander (Ambystoma gracile) embryo with the algae from the Northeast salamander (Ambystoma maculatum) embryo during their early embryonic development. Therefore, one of the major purposes of this trip is to collect adequate Northwest salamander embryos for the experiment.

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Ambystoma gracile (AKA: the northwestern salamander) mainly inhabits the northwest coast of North America, hence the name northwestern salamander.
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Egg mass of the northwest salamander. The salamander eggs usually form a egg clutch that is coated with clear-looking, firm jelly on the outside to protect them. Did it ever occur to you that these beautiful eggs look like the bubbles in the bubble tea?

Of course Kerney lab has our own ways of doing trips! We rented a R.V., which not only was our living space at night, but also our lab space during the day. The R.V. also functioned as our mobile vehicle when we needed to travel as well as our kitchen and dining space when we needed to eat – it was as convenient as you want it to be. If you are wondering how much of a lab can be made from a R.V., you would be very surprised. Fluorescent microscope, dissecting microscope, full range of chemicals, pH meter, salinity meter, dissecting tools, centrifuge tubes, and even waste disposal were all equipped in this tiny R.V, crazy… isn’t it?

Busy crew inside the “mobile lab”.
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Similar to when doctors take out water samples from pregnant mother to test the living conditions of the babe, here we also take out the fluid surrounding the salamander baby inside the egg capsule to to chemically analysis the aquatic environment in which the embryo lives in.

You might be curious about how this trip itself went. I would say, the trip was absolutely incredible! During the seven-day trip, the crew have traveled across the entirety of Oregon state and Washington state and the furthest place we reached North was Bellingham, WA. Under states permits we collected and fixed salamander embryos from seven sites, including natural parks, local ponds, and the backyard of a few newfound friends.

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Grandma, grandpa, mom, dad, and the little young boy were all working hard to find help us find salamander eggs in their backyard!
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To express our gratitude to the family for helping us for the salamander egg hunt and offering us the delicious dinner, we invited the family into our “mobile lab” and fired up the florescent microscope to show them some cool stuff about science.

What was the most unforgettable memory for me from this trip? I would definitely say the amazing scenery and the friendly people we’ve met. Not only did we cold hike through the ancient temperate rain forests, but we also saw snow-capped volcanoes, coasts, and some old train trails in northwest. Thanks to this amazing trip, the Pacific Northwest was, is, and will always be a true wonderland from the bottom of my heart. In a simple phrase, the trip was truly “breaking good”!

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Picture of our Pacific Northwest collection crew. From left to right: Jasper Leavitt ’15, Huanjia Zhang (myself), Kyle Weis, Ryan Kerney, and John Burns.

Read more about the spotted salamander (Ambystoma maculatum) and its symbiosis relationship with green algae.

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